PMID

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Article Title

Organization

Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.

University of Texas At Dallas

Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives.

State Key Laboratory of Bioreactor Engineering

On dihydroorotate dehydrogenases and their inhibitors and uses.

Institut Pasteur

Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.

State Key Laboratory of Bioreactor Engineering

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

St. Jude Children'S Research Hospital

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.

Harvard School of Public Health

Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.

Hoechst Marion Roussel

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.

Universit£

Biaryl analogues of teriflunomide as potent DHODH inhibitors.

RhôNe-Poulenc Rorer

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

University of Washington

1,2,5-Oxadiazole analogues of leflunomide and related compounds.

Universit£

Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl derivatives.

Tunghai University

-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.

Janssen Research and Development

SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors.

4Sc

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.

University of Washington

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.

University of Washington

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.

The Walter and Eliza Hall Institute of Medical Research

Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.

University of Turin

In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

Harvard School of Public Health

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Harvard Medical School

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.

University of Leeds

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.

University of Washington At Seattle

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

University of Texas At Dallas

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.

University of Copenhagen

Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors.

4Sc

The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

University of Leeds

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

University of Texas Southwestern Medical Center

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

University of Leeds